TIMELESS CLOCK
نویسندگان
چکیده
منابع مشابه
CULLIN-3 Controls TIMELESS Oscillations in the Drosophila Circadian Clock
Eukaryotic circadian clocks rely on transcriptional feedback loops. In Drosophila, the PERIOD (PER) and TIMELESS (TIM) proteins accumulate during the night, inhibit the activity of the CLOCK (CLK)/CYCLE (CYC) transcriptional complex, and are degraded in the early morning. The control of PER and TIM oscillations largely depends on post-translational mechanisms. They involve both light-dependent ...
متن کاملperiod and timeless Tango: A dance of two clock genes
Circadian rhythms are genetically determined biological oscillations evident in virtually all plants and animals, and even some prokaryotes. Circadian rhythms are generated by endogenous timing mechanisms referred to as biological or circadian clocks. Signature features of circadian clocks include an endogenous cycle length (period) of about 24 hr, daily sensitivity to resetting (entraining) st...
متن کاملThe Drosophila clock protein Timeless is a member of the Arm/HEAT family
In higher eukaryotes, the circadian clock is generated by a system of negative and positive autoregulatory feedback loops [1]. In Drosophila, the negative limb of this mechanism involves the Timeless (Tim) and Period (Per) proteins, which must physically associate in order to be translocated to the nucleus. Once inside, the Per–Tim heterodimer negatively regulates the expression of the per and ...
متن کاملLight-Dependent Interactions between the Drosophila Circadian Clock Factors Cryptochrome, Jetlag, and Timeless
Circadian clocks regulate daily fluctuations of many physiological and behavioral aspects in life. They are synchronized with the environment via light or temperature cycles [1]. Natural fluctuations of the day length (photoperiod) and temperature necessitate a daily reset of the circadian clock on the molecular level. In Drosophila, the blue-light photoreceptor Cryptochrome (Cry) mediates a ra...
متن کاملAn Unexpected Role for the Clock Protein Timeless in Developmental Apoptosis
BACKGROUND Programmed cell death is critical not only in adult tissue homeostasis but for embryogenesis as well. One of the earliest steps in development, formation of the proamniotic cavity, involves coordinated apoptosis of embryonic cells. Recent work from our group demonstrated that c-Src protein-tyrosine kinase activity triggers differentiation of mouse embryonic stem (mES) cells to primit...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2007
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.001180